Trehalose (TreMoisture™)
Trehalose is a naturally occurring non‐reducing disaccharide that has been shown to exert multiple protective effects when applied topically. Its benefits stem largely from its unique ability to stabilize proteins and lipid membranes, protect cells from desiccation and oxidative stress, and even modulate autophagy. Here are some of the key topical benefits supported by research
Skin Barrier Enhancement and Moisturization
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Hydration and Barrier Function: Trehalose’s strong water‐binding (kosmotropic) properties help it act as a humectant. When included in cosmetic formulations, trehalose can enhance skin hydration and improve the barrier function by stabilizing the proteins and lipids in the stratum corneum. This helps reduce transepidermal water loss and restores the skin’s natural moisture balance.
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Wound Healing: Research indicates that trehalose can induce a transient, beneficial senescence‐like state in skin fibroblasts by modulating autophagy. This cellular response is associated with reduced apoptosis and oxidative stress, as well as enhanced angiogenesis—all factors that contribute to more efficient wound repair and improved skin flap survival in reconstructive settings.
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Cosmetic Applications: In cosmetic dermatology, formulations combining trehalose with other ingredients (e.g., ceramides) have been shown to reinforce the skin’s barrier, improve moisture retention, and offer a soothing effect against irritation—benefits that are especially important in conditions like atopic dermatitis.
Mechanistic Insights
Trehalose’s multifaceted benefits are linked to several cellular mechanisms:
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Protein and Membrane Stabilization: By forming hydrogen bonds with proteins and lipids, trehalose replaces water molecules during dehydration, thus preserving cellular structure and function.
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Autophagy Modulation: Trehalose can induce autophagy independent of the mTOR pathway. This not only helps clear damaged proteins and organelles but also promotes cell survival and tissue repair in both the skin and corneal cells.
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Antioxidant Effects: By reducing oxidative stress, trehalose limits the damage caused by reactive oxygen species—a benefit that is critical for maintaining both skin and ocular health.
Usage: For mixing in all products.
Mixing method: Mix in water.
Usage rate: 1-3%
Product appearance: white powder
Solubility: Soluble in water.
INCI Name : Trehalose
