L-Pyroglutamic Acid (PCA) or Pyrrolidone Carboxylic Acid (PCA) is commonly used as a moisturizing agent in skincare formulations. Specifically, its sodium salt (Sodium PCA) is frequently cited for topical benefits. Here's a summary of well-documented topical benefits with supporting research citations:
Topical Benefits of PCA:
- Hydration and Moisturization
- PCA acts as a natural moisturizing factor (NMF), significantly enhancing skin hydration by attracting and retaining moisture from the environment.
- Sodium PCA has high water-binding capabilities, helping restore and maintain the skin's hydration barrier.
Scientific Evidence:
- Humectant Activity:
- Sodium PCA increases the water-holding capacity of the stratum corneum, significantly improving skin hydration (Warner et al., 2003).
- Barrier Function Improvement:
- PCA derivatives have been demonstrated to enhance the structural integrity of the skin barrier, which is vital for preventing transepidermal water loss (Rawlings & Harding, 2004).
- Skin Smoothing and Softening:
- Topical application of formulations containing PCA leads to improved skin texture and smoothness, confirmed by clinical studies (Lodén, 2003).
- Protection Against Irritation:
- PCA may help reduce irritation and inflammation associated with topical treatments by improving the skin’s hydration level and barrier integrity (Fluhr et al., 2001).
- Enhanced Skin Elasticity:
- Sodium PCA has shown efficacy in maintaining or improving skin elasticity, which can support anti-aging effects (Wickett & Visscher, 2006).
Common Applications:
- Moisturizing creams, serums, and lotions.
- Anti-aging formulations.
- Barrier creams to alleviate dryness and prevent irritation.
- Sensitive skin preparations.
How to use: For all types of cosmetics, available in gel, serum, lotion or cream form.
Mixing method: Mix directly into the formula in water (water phase).
Usage rate: 0.1-3%
Product characteristics: Solid powder
Solubility: Can be dissolved in water immediately.
Storage: For long-term storage, keep in the refrigerator, avoid sunlight and heat. Shelf life is at least 2 years.
INCI Name : PCA
