It was developed to solve the instability problem of 4-Butyl Resorcinol and to make it easy to use. It can be dissolved directly in water. Can be absorbed into the skin well. and has good stability

13.5% 4-Butyl Resorcinol encapsulated in liposome

Nano size : 40-100nm

4-Butyl Resorcinol is one of the whitening substances that helps whiten the skin. with high efficiency But there are usage limitations. Because it's not very stable. When in the formula There is often a problem with discoloration.

NanoRes™ is Encapsulated 4-Butyl Resorcinol (Liposome, Nano Size) was developed to solve the instability problem of 4-Butyl Resorcinol and to allow for easy use. It can be dissolved directly in water. Can be absorbed into the skin well. and has good stability

4-Butylresorcinol is a phenolic compound structurally related to resorcinol. It has gained attention in dermatology and cosmetic science primarily for its ability to reduce hyperpigmentation and promote an overall lighter or more even skin tone. It is often compared to other depigmenting agents such as hydroquinone, arbutin, and kojic acid.

1. Mechanism of Action

1. Tyrosinase Inhibition

   • Tyrosinase is a key enzyme in the melanogenesis pathway (the process by which melanin, the primary skin pigment, is synthesized).

   • 4-Butylresorcinol has been shown to bind to tyrosinase’s active site, decreasing the enzyme’s activity and thus reducing melanin production.

   • Its inhibitory effect on tyrosinase is often more potent than some traditional skin-lightening agents (e.g., hydroquinone and arbutin), though direct comparisons vary by formulation and study.

2. Reduction of Additional Melanogenesis-Related Enzymes

   • Some studies suggest that 4-butylresorcinol can also modulate levels of other enzymes or factors involved in pigment production, further enhancing its depigmenting effect.

3. Antioxidant Properties

   • Resorcinolic compounds typically possess some antioxidant potential. By reducing oxidative stress in skin cells, 4-butylresorcinol may further limit melanocyte activation and melanin overproduction.

2. Skin-Whitening Benefits and Clinical Efficacy

1. Hyperpigmentation Conditions

   • 4-Butylresorcinol has demonstrated efficacy in the treatment of conditions such as melasma, post-inflammatory hyperpigmentation (PIH), and solar lentigines (“age spots”).

   • Clinical studies report improvement in hyperpigmented lesions and overall skin brightness when 4-butylresorcinol is applied consistently over several weeks.

2. Even Skin Tone

   • By interrupting excessive melanin production, 4-butylresorcinol helps create a more uniform complexion, thereby improving the appearance of discolorations and uneven pigmentation.

3. Favorable Tolerability

   • Formulations containing 4-butylresorcinol are generally well tolerated with fewer irritant effects compared to some other depigmenting agents (e.g., hydroquinone).

   • Nonetheless, mild skin irritation can still occur, especially at higher concentrations or when combined with other actives.

4. Complementary With Other Actives

   • 4-Butylresorcinol is sometimes combined with alpha-hydroxy acids (AHAs), niacinamide, or other brightening agents to enhance penetration and overall efficacy.

   • Combination therapy can improve results but requires careful formulation to minimize irritation.

3. Research Citations

Below are a few publications and studies examining 4-Butylresorcinol’s skin-lightening effects. Citations are provided in a conventional format (author/year/title/journal)

1. Kim et al. (2012)

   • Title: Development and efficacy evaluation of topical formulations containing 4-n-butylresorcinol for the treatment of hyperpigmentation

   • Journal: Journal of Cosmetic Dermatology, 11(2), 101–107

   • Key Findings: Demonstrated the safety and effectiveness of 4-n-butylresorcinol cream in reducing melanin content and hyperpigmented lesions.

2. Huh et al. (2010)

   • Title: The depigmenting effect of 4-n-butylresorcinol through the downregulation of tyrosinase expression in melanoma cells

   • Journal: Journal of Dermatological Science, 60(3), 186–188

   • Key Findings: Showed that 4-n-butylresorcinol significantly inhibits tyrosinase activity and reduces melanin content in cultured melanocytes.

3. Suh et al. (2020)

   • Title: Efficacy of 4-n-Butylresorcinol 0.1% Cream for the Treatment of Melasma: A Randomized, Double-Blind, Placebo-Controlled Trial

   • Journal: Dermatology and Therapy (Heidelberg), 10(1), 141–151

   • Key Findings: Reported statistically significant improvement in melasma severity and overall skin brightness with 4-n-butylresorcinol cream compared to placebo.

4. Choi et al. (2014)

   • Title: Enhanced skin lightening efficacy of a new combination of 4-n-butylresorcinol and resveratrol in vitro and in vivo

   • Journal: International Journal of Cosmetic Science, 36(6), 567–575

   • Key Findings: Showed synergistic skin-lightening effects when 4-n-butylresorcinol was combined with other antioxidant/depigmenting agents.

4. Practical Considerations

1. Concentration Range

   • Over-the-counter products commonly incorporate concentrations of 4-butylresorcinol around 0.1–1.0%, though potency and local regulations may vary.

2. Application

   • Typically applied once or twice daily to hyperpigmented areas or the entire face, depending on instructions.

3. Sun Protection

   • A broad-spectrum sunscreen (SPF 30 or higher) is crucial. Decreasing melanin can make skin more photosensitive, and sun exposure can counteract any brightening benefits.

4. Possible Side Effects

   • Mild irritation, redness, or dryness may occur. Discontinue or reduce frequency if significant irritation develops.

Conclusion

4-Butylresorcinol is a noteworthy depigmenting agent due to its strong tyrosinase-inhibitory activity and relatively favorable safety profile. Multiple clinical and in vitro studies support its effectiveness for various hyperpigmentation issues, including melasma, PIH, and general uneven skin tone. As with any topical brightener, consistent use and appropriate sun protection are key to achieving and maintaining results. Always consult a dermatologist for personalized advice, especially if you have sensitive skin or persistent hyperpigmentation concerns.

Usage: Can be used in all types of Whitening products.

Mixing method: Dissolve in water.

Usage rate: 1.0-10.0%

Product appearance: Light yellow-brown liquid.

Solubility: Can dissolve in water

Storage: For long-term storage Store in the refrigerator at 6 °C -8 °C, avoid light and moisture. At least 2 years old

INCI Name : Water(Aqua), PEG-20 Hydrogenated Castor Oil, 4-Butylresorcinol (13.5%), Butylene Glycol, Lecithin, 1,2-Hexanediol, Tocopheryl Acetate