Calcium L-methylfolate or Vitamin B9

1. Cardiovascular Health & Homocysteine Reduction

L-5-MTHF-Ca supports the remethylation of homocysteine to methionine, effectively lowering plasma homocysteine (tHcy) levels—an independent cardiovascular risk factor. Studies show that L-5-MTHF is as effective as folic acid in reducing tHcy levels, with improved endothelial function and reduced oxidative stress in vascular tissues.
Reference:

• Henderson AM, Aleliunas RE, Loh SP, et al. J Nutr. 2018;148(6):885–890.

• Pawlak R, et al. Circulation. 2006;113(11):1454–1459.

2. Neuropsychiatric Support in Depression

L-5-MTHF-Ca enhances antidepressant efficacy, especially in individuals with MTHFR polymorphisms. It helps regulate neurotransmitter synthesis (e.g., serotonin, dopamine) through methylation processes. In several clinical trials, it improved treatment outcomes in major depressive disorder and treatment-resistant depression.
Reference:

• Miller AL. J Clin Psychiatry. 2008;69(3):659–662.

• Papakostas GI, et al. Psychiatric Annals. 2012;42(6):317–321.

3. Cognitive Function & Neurological Health

Elevated homocysteine and folate deficiency are linked to cognitive decline and Alzheimer’s disease. L-5-MTHF-Ca improves methylation in brain tissues and reduces neurotoxic homocysteine levels, supporting cognitive function, especially in elderly or folate-deficient individuals.
Reference:

• Bottiglieri T. Am J Clin Nutr. 1996;64(4):715–723.

• McCaddon A, et al. Am J Psychiatry. 2002;159(12):2096–2098.

4. Maternal and Fetal Health

L-5-MTHF-Ca is an active form of folate that crosses the placenta and supports fetal neural tube development without requiring enzymatic conversion. It avoids the issue of unmetabolized folic acid (UMFA) seen in some populations. Some studies report a lower incidence of preeclampsia and better maternal-fetal folate status compared to folic acid.
Reference:

• Green TJ, et al. Am J Clin Nutr. 2010;92(3):548–553.

• Tamura T, Picciano MF. Am J Clin Nutr. 2006;83(3):529–552.