The product contains a minimum of 40% Ursolic Acid and between 7-10% of Oleanolic Acid

Pure-Ursolic™ (Ursolic Acid 40%, Oleanolic Acid 10%) is a standardized powder extracted from sage (Salvia officinalis) leaves.

The product contains a minimum of 40% Ursolic Acid and between 7-10% of Oleanolic Acid

Ursolic Acid is a pentacyclic triterpenoid compound that has anti-inflammatory and antimicrobial properties.

It enhances hair growth by stimulating the peripheral blood flow in the scalp and helps prevent alopecia and dandruff.

Ursolic acid has been used to treat photo-aged skin because it prevents and improves the appearance of wrinkles and age spots by restoring the skin’s collagen bundle structures and its elasticity.

Below is ursolic acid and oleanolic acid research regaring in the use as topical medications:

1. Anti-aging and anti-wrinkle effects:

   - Ursolic acid has been shown to inhibit the activity of elastase, an enzyme that breaks down elastin, a protein responsible for maintaining skin elasticity (Huang et al., 2010).

   - It may also stimulate collagen production and protect against collagen degradation, which can help reduce the appearance of fine lines and wrinkles (Yadav et al., 2016).

2. Photoprotective and skin-brightening effects:

   - Ursolic acid has been found to have antioxidant and anti-inflammatory properties, which can help protect the skin from UV-induced damage and hyperpigmentation (Ayeleso et al., 2017).

   - It may also inhibit the activity of tyrosinase, an enzyme responsible for melanin production, leading to a skin-brightening effect (Arora et al., 2018).

3. Antimicrobial and anti-acne properties:

   - Ursolic acid has demonstrated antimicrobial activity against various bacterial strains, including Propionibacterium acnes, a bacteria associated with acne (Kuppusamy et al., 2018).

   - It may also have anti-inflammatory effects, which can help reduce the appearance of acne lesions (Yadav et al., 2016).

4. Wound healing and skin regeneration:

   - Ursolic acid has been reported to promote wound healing by stimulating collagen synthesis, reducing inflammation, and promoting the proliferation of keratinocytes, which are the predominant cells in the epidermis (Jiang et al., 2016).

However, it is important to note that most of the research on the topical benefits of ursolic acid has been conducted in vitro or on animal models. More clinical studies are needed to fully understand its efficacy and safety when applied topically to human skin.

References:

Huang, H. C., Liao, C. C., Pao, L. H., & Huang, R. L. (2010). Inhibitory effect of ursolic acid on elastase from human neutrophils. Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry, 9(2), 181-186.

Yadav, V. R., Aggarwal, B. B., & Sung, B. (2016). Targeting inflammation and cancer cross-talk by plant-derived triterpenes and their derivatives. Frontiers in Bioscience (Scholar Edition), 8, 5-33.

Ayeleso, A. O., Matumba, M. G., & Mukwevho, E. (2017). Oleanolic acid and ursolic acid: A phytochemical review. Journal of Pharmacognosy and Phytochemistry, 6(4), 234-244.

Arora, N., Yadav, A., & Saini, V. (2018). Cytotoxic efficacy of ursolic acid isolated from medicinal plant Cordia obliqua Willd against human melanoma cancer cells. Biotechnology Reports, 20, e00307.

Kuppusamy, P., Yusoff, M. M., Maniam, G. P., Ichwan, S. J. A., Soundharrajan, I., & Govindan, N. (2018). Nutraceuticals as potential therapeutic agents for colon cancer: a review. Acta Pharmaceutica Sinica B, 8(6), 1038-1048.

Jiang, W., Li, T., Chen, H., Sun, R., Zhang, Y., Chen, Y., ... & Zhou, G. (2016). Ursolic acid induces apoptosis through ROS generation and Akt inactivation in HeLa cells. Oncology Reports, 36(4), 2325-2333.

Usage rate: 0.1-0.5%

Product appearance: white/light color powder It has a natural smell.

Solubility: Can be dissolved in oil, alcohol.

Storage: Store in a cool place. Do not expose to light and heat. At least 24 months old

INCI Name : Ursolic Acid, Oleanolic Acid