quinolizidine alkaloid derived from the Sophora plant species, particularly from Sophora flavescens. Like matrine, oxymatrine has been used in traditional Chinese medicine and exhibits several potential benefits when applied topically, such as anti-inflammatory, anti-oxidant, anti-aging, and skin-whitening properties

Oxymatrine is a quinolizidine alkaloid derived from the Sophora plant species, particularly from Sophora flavescens. Like matrine, oxymatrine has been used in traditional Chinese medicine and exhibits several potential benefits when applied topically, such as anti-inflammatory, anti-oxidant, anti-aging, and skin-whitening properties.

Topical Benefits of Oxymatrine

1. Anti-inflammatory Properties: Oxymatrine has been shown to significantly reduce inflammation by suppressing the production of pro-inflammatory cytokines and inhibiting signaling pathways like NF-κB. This property makes it beneficial for conditions such as dermatitis, psoriasis, and acne.

   • Research Citation: Zhang, L., Xing, R., Huang, Y., Xue, H., Zhang, Z., & Zhang, L. (2018). Oxymatrine protects against lipopolysaccharide-induced inflammation in microglial cells by inhibiting the NF-κB signaling pathway. Mediators of Inflammation, 2018, 1-9. DOI:10.1155/2018/8563494

2. Anti-oxidant Effects: Oxymatrine has been shown to exhibit antioxidant properties, helping to protect the skin from oxidative stress caused by free radicals, which can lead to premature aging and skin damage.

   • Research Citation: Huang, Y., Yang, J., Wang, T., Zhao, S., & Wang, C. (2017). Antioxidant and anti-inflammatory effects of oxymatrine on rats with colitis. BMC Complementary and Alternative Medicine, 17(1), 202. DOI:10.1186/s12906-017-1698-6

3. Anti-aging Effects: Oxymatrine has been found to inhibit the activity of matrix metalloproteinases (MMPs), enzymes that break down collagen in the skin. This action can help reduce the appearance of wrinkles and improve skin elasticity.

   • Research Citation: Tang, X., Zhou, S., Li, Z., Zhang, Z., & He, J. (2014). Oxymatrine inhibits UV-induced MMP expression in human skin fibroblasts by regulating the NF-κB pathway. International Journal of Dermatology, 53(5), 673-679. DOI:10.1111/ijd.12215

4. Skin-whitening Effects: Oxymatrine has been shown to reduce melanin production, which can help in lightening hyperpigmented areas and achieving a more even skin tone.

   • Research Citation: Zeng, H., Wang, Z., Zhang, X., & Zhu, W. (2011). Oxymatrine inhibits melanogenesis through the suppression of tyrosinase expression in B16 cells. Journal of Dermatological Science, 62(1), 40-42. DOI:10.1016/j.jdermsci.2011.01.006

Usage: Can be used in anti-irritation products.

How to mix: Mix in the formula in the last step. Avoid heat.

Usage rate: 0.1-1.0%

Product appearance: white to off-white powder

Solubility: Soluble in water

Storage: For long-term storage Store in the refrigerator. Avoid exposure to light or heat. Seal the lid tightly. Shelf life is at least 2 years.

INCI Name : Sophora Flavescens Root Extract