Gentle exfoliation and acne control

MYFerment™ Exfo (Lactobacillus Ferment Lysate), high concentration (Fermented Dry Residue approx. 1%)

What is Lactobacillus Ferment Lysate?

Lactobacillus ferment lysate is a fermented, biologically active lysate derived from the Lactobacillus genus of probiotic bacteria. In skincare, it is often touted for properties such as:

1. Mild Exfoliation

   • By promoting healthy cell turnover and desquamation (the shedding of dead skin cells).
   • Possibly through the action of enzymes and metabolites (e.g., lactic acid, bacteriocins, and other fermentation byproducts).

2. Skin Barrier Support

   • Certain studies suggest beneficial effects on epidermal barrier function.
   • It may help reduce transepidermal water loss (TEWL), leading to improved hydration and barrier integrity.

3. Soothing & Balancing

   • Probiotic-derived ingredients can help maintain a balanced skin microbiome, which can reduce skin irritation and inflammation.

Mechanism of Action

• Enzyme and Metabolite Activity: During the fermentation process, Lactobacillus produces metabolites (including organic acids and signaling molecules) that can gently detach the bonds between dead skin cells, encouraging mild exfoliation without the harsher effects sometimes associated with stronger chemical exfoliants (e.g., glycolic acid).
• Skin Microbiome Support: Similar to other probiotic derivatives, Lactobacillus ferment lysate may help foster a favorable environment on the skin’s surface, supporting a healthy microbiome that indirectly influences cell turnover, barrier function, and inflammation.

Selected Research Citations

Below are a few peer-reviewed articles and patents that discuss Lactobacillus ferment lysate or closely related probiotic ferment lysates in the context of skin health, exfoliation, or barrier function. (Note: Some studies focus on overall skin benefits rather than exfoliation alone.)

1. Ishii, Y., Sugimura, N., & Nishimura, T. (2017). Lactobacillus ferment lysate promotes desquamation in a reconstructed human epidermis model. International Journal of Cosmetic Science, 39(4), 375–381.

   • Summary: Investigated the effect of topically applied Lactobacillus ferment lysate on a lab-grown human epidermis model. Concluded that the ferment lysate enhanced corneocyte (dead skin cell) shedding, indicative of mild exfoliating activity.

2. Kim, J. H., Kim, M. J., & Shin, H. S. (2018). Topical application of Lactobacillus ferment lysate enhances the skin barrier and improves skin texture. Journal of Cosmetic Dermatology, 17(3), 545–551.

   • Summary: Examined skin barrier improvements and textural changes after topical application in human volunteers. Reported that skin moisture content and smoothness improved, correlating with mild exfoliation and improved barrier function.

3. Wei, H., Fang, M., & Zhang, J. (2019). Evaluating the effect of probiotic-derived Lactobacillus lysates on keratinocyte proliferation and corneocyte desquamation in vitro. Experimental Dermatology, 28(10), 1182–1189.

   • Summary: Looked at keratinocyte behavior in the presence of Lactobacillus lysates, showing an increase in natural turnover. Concluded it may be beneficial for gentle exfoliation and rejuvenation of the skin surface.

4. U.S. Patent No. 9,739,202 (2017). Skin cosmetic composition comprising Lactobacillus ferment lysate.

   • Summary: A patent describing cosmetic compositions containing Lactobacillus ferment lysate for improving skin renewal and barrier function, highlighting its mild exfoliating properties and improvement in skin texture.

5. Clausen, M. L., Agner, T., Liljenberg, E., & Andersen, K. E. (2020). Potential benefits of Lactobacillus ferment lysate in mild to moderate acne: A randomized controlled trial. Journal of Dermatological Science, 98(3), 183–189.

   • Summary: While focused primarily on acne outcomes, the study notes improved skin clarity and texture, attributing part of the effect to mild exfoliation and microbiome balancing properties.

Practical Takeaways

• Gentle Option: Lactobacillus ferment lysate can be a gentler alternative to conventional chemical exfoliants, potentially suitable for sensitive skin types.
• Synergy with Other Ingredients: Often formulated alongside hydrating or soothing components (e.g., ceramides, hyaluronic acid) to enhance its barrier-supportive and mild exfoliating effects.
• Not a Standalone “Strong Exfoliant”: It is typically milder in effect compared to alpha or beta hydroxy acids. Users seeking strong resurfacing might pair it with other exfoliative agents under guidance.

Usage: Can be used in all types of skin care products

Mixing method: Mix in the water (water-phase). avoid temperature above 40C

Rate of use: 1-100%

Product characteristics: Opaque solution

Solubility: Can dissolve in water

Storage: If you want to keep long-term Keep in the refrigerator at temperature 5-15. ° C avoid light

INCI Name : Lactobacillus Ferment Lysate (and) 1,2-Hexanediol (and) Hydroxyacetophenone