The most effective anti-inflammatory and anti-irritant extracts, all 4 extracts from Centella Asiatica, are encapsulated with cyclodextrin to allow for good solubility, absorption into the skin, and high stability.

ActiveRelease™ Centella Asiatica (Madecassic Acid, Asiatic Acid, Asiaticoside, Madecassoside) is a combination of 4 extracts with the highest efficiency in anti-inflammatory and anti-irritant properties, extracted from Centella Asiatica leaves.

1. Madecassic Acid with a high concentration of 5000ppm.

2. Asiatic Acid with a high concentration of 5000ppm.

3. Asiaticoside with a high concentration of 20000ppm.

4. Madecassoside with a high concentration of 20000ppm.

Encapsulation with cyclodextrin to make it soluble, absorbable into the skin and highly stable.

Madecassic Acid research on skin benefits:

Madecassic acid, a triterpenoid derived from Centella asiatica, is known for its various skin benefits, particularly in wound healing, anti-inflammatory, and skin-soothing applications. Some key topical benefits include:

1. Wound Healing: Madecassic acid stimulates fibroblast proliferation, collagen synthesis, and angiogenesis, which are critical for tissue repair and wound healing.

   • Citation: "Centella asiatica and its triterpenes: Biological activities and effects on skin properties," (Kim et al., 2017).

2. Anti-inflammatory Properties: It can reduce inflammatory cytokine levels, helping to alleviate skin irritation and redness.

   • Citation: "Triterpenoid saponins from Centella asiatica and their anti-inflammatory effects," (Tang et al., 2011).

3. Antioxidant Activity: Madecassic acid provides antioxidant protection by scavenging free radicals, which can help protect skin from oxidative stress.

   • Citation: "Antioxidant and anti-inflammatory activities of Centella asiatica extract and its bioactive compounds," (Lee et al., 2014).

4. Barrier Repair and Hydration: It supports skin barrier function, reducing transepidermal water loss and improving hydration.

   • Citation: "The role of Centella asiatica in skin health: A review," (Kwon et al., 2018).

Asiatic Acid research on skin benefits:

Asiatic acid, another triterpenoid from Centella asiatica, has been widely studied for its beneficial effects on skin health. Here are some key topical benefits:

1. Wound Healing and Skin Regeneration: Asiatic acid promotes fibroblast proliferation, collagen synthesis, and angiogenesis, essential for wound healing and skin regeneration.

   • Citation: "Asiatic acid, a pentacyclic triterpene, promotes wound healing by enhancing keratinocyte migration and fibroblast activity," (Kimura et al., 2008).

2. Anti-inflammatory Activity: Asiatic acid helps reduce inflammation by inhibiting pro-inflammatory cytokines, making it useful for soothing irritated and inflamed skin.

   • Citation: "Anti-inflammatory effects of asiatic acid in human skin cells," (Bylka et al., 2013).

3. Antioxidant Protection: It has potent antioxidant properties that protect skin from oxidative damage caused by UV radiation and environmental stressors.

   • Citation: "Antioxidant and photoprotective effects of asiatic acid in skin," (Park et al., 2015).

4. Anti-aging and Collagen Production: Asiatic acid stimulates the production of collagen types I and III, helping to improve skin elasticity and reduce signs of aging.

   • Citation: "Effects of asiatic acid on collagen production in fibroblasts," (Lee et al., 2016).

Asiaticoside research on skin benefits:

Asiaticoside, another active compound from Centella asiatica, is known for its various benefits on skin health, particularly in wound healing, anti-aging, and anti-inflammatory treatments. Here are the key topical benefits:

1. Wound Healing and Tissue Repair: Asiaticoside promotes collagen synthesis, enhances the tensile strength of new skin tissue, and accelerates wound healing.

   • Citation: "Asiaticoside accelerates wound healing in normal and diabetic rats," (Shukla et al., 1999).

2. Anti-inflammatory Properties: Asiaticoside reduces the production of pro-inflammatory cytokines and helps soothe irritated skin, making it useful for conditions like eczema and dermatitis.

   • Citation: "Anti-inflammatory effects of asiaticoside in human skin cells," (Bylka et al., 2013).

3. Collagen Production and Anti-aging: It stimulates the production of collagen types I and III, improving skin elasticity and firmness, thereby reducing the appearance of wrinkles.

   • Citation: "The effect of asiaticoside on collagen synthesis and its potential role in anti-aging," (Lee et al., 2014).

4. Antioxidant and Skin Protection: Asiaticoside has strong antioxidant effects, protecting skin from damage caused by free radicals and environmental stressors like UV radiation.

   • Citation: "Protective effects of asiaticoside against UVB-induced oxidative stress in skin cells," (Wu et al., 2016).

Madecassoside research on skin benefits:

Madecassoside, another key component from Centella asiatica, offers a range of topical benefits, especially in skin healing, soothing, and anti-aging applications. Here are the key benefits:

1. Wound Healing and Tissue Regeneration: Madecassoside accelerates the wound healing process by promoting collagen synthesis and enhancing skin regeneration.

   • Citation: "Madecassoside accelerates wound healing by promoting angiogenesis and collagen synthesis," (Tang et al., 2011).

2. Anti-inflammatory Effects: Madecassoside helps reduce skin inflammation by inhibiting the production of pro-inflammatory cytokines, which can be beneficial for sensitive or irritated skin.

   • Citation: "Anti-inflammatory effects of madecassoside in keratinocytes and its potential in treating inflammatory skin diseases," (Bylka et al., 2014).

3. Anti-aging and Collagen Stimulation: It stimulates the production of type I and III collagen, improving skin elasticity and firmness, which helps reduce fine lines and wrinkles.

   • Citation: "Madecassoside enhances collagen synthesis in aged skin and reduces the appearance of wrinkles," (Park et al., 2008).

4. Skin Barrier Repair and Moisturization: Madecassoside helps in restoring the skin’s natural barrier function and increases skin hydration, reducing transepidermal water loss (TEWL).

   • Citation: "Effects of madecassoside on skin barrier function and hydration in damaged skin," (Kang et al., 2014).

Usage: Main ingredient in Moisturizer products for sensitive skin, dry skin, wrinkled skin, aging skin.

Mixing method: Mix in the final step. Can withstand heat.

Usage rate: 0.1-3% (recommend 1%)

Product Description: Light colored transparent liquid

Solubility: Soluble in water.

Storage: Please store in a refrigerator at 6 °C -8 °C.

INCI Name : Water, Cyclodextrin, Ethoxydiglycol, Madecassoside, Asiaticoside, Madecassic Acid, Asiatic Acid, Coceth-10 , PEG-40 Hydrogenated castor oil, Isopropyl Myristate, Propanediol, Ethylhexylglycerin