bioactive lipid mediator with several potential health benefits, particularly related to obesity, inflammation, and oxidative stress

Oleoylethanolamide (OEA) is a bioactive lipid mediator with several potential health benefits, particularly related to obesity, inflammation, and oxidative stress. The following are the key health benefits of OEA based on the provided sources:

Anti-inflammatory and Antioxidant Effects
- OEA supplementation has been shown to reduce inflammation in obese individuals by significantly decreasing serum concentrations of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) [1].
- It also has antioxidant properties, which may help reduce oxidative stress, although changes in malondialdehyde (MDA), total antioxidant status (TAS), and high sensitive-C reactive protein (hs-CRP) were not significant in the study[1].

Weight Management and Satiety
- OEA is known to induce a feeling of satiety after meals, which can aid in weight management[3].
- It has been observed to reduce appetite and body weight in obese individuals through the activation of the nuclear receptor PPAR-alpha[2][5].
- In animal studies, both injections and oral intake of OEA caused a reliable reduction in the amount of food eaten[3].

Effects on Gut Microbiota and Intestinal Health
- OEA treatment can affect gut microbiota composition and enhance the expression of intestinal cytokines in Peyer’s patches, which are important for protective mucosal immune responses[4].
- It may also contribute to a less inflammatory milieu in the gut[4].

Potential for Treating Metabolic Disorders
- OEA has been proposed as a candidate for the treatment of non-alcoholic fatty liver disease due to its PPAR-alpha activation properties[2].

Pain Management
- Among women with dysmenorrhea (painful menstruation), supplementing with OEA reduced pain severity and improved markers of inflammation[3].

Potential Neurological and Psychological Benefits
- OEA may help control depression through hormonal and neurological patterns, as observed in animal studies[5].
- It has been shown to reduce unpredictable mild stress in animal models[5].

Hormonal Balance
- OEA supplementation may regulate hormonal balance and neurotransmitter production in the brain[5].

Appetite Regulation
- OEA reduces the levels of appetite-stimulating hormones like peptide YY (PYY), which can lead to enhanced satiety and potentially support fat-burn enhancement[5].


Citations:
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156479/
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119414/
[3] https://examine.com/supplements/oleoylethanolamide/
[4] https://www.nature.com/articles/s41598-018-32925-x
[5] https://www.nutriavenue.com/n-oleoylethanolamide-a-must-have-compound-in-weight-loss-2/