Skin barrier reinforcement and soothing

MYFerment™ Barrier (Lactococcus Ferment Extract)

What is Lactococcus Ferment Extract?

• Source: Lactococcus ferment extract is typically derived from the fermentation of Lactococcus lactis, a probiotic bacterium widely used in the food and dairy industries (e.g., cheese production).
• Form: In skincare, the ingredient is often used as a filtrate or lysate (sometimes labeled “Lactococcus Ferment Lysate”), which contains soluble bioactive components produced or released by the bacterium during fermentation.

Potential Skin Barrier Benefits

1. Enhancement of Skin Barrier Proteins

   • Research indicates that Lactococcus ferment extract can upregulate key structural proteins in the epidermis—such as filaggrin, involucrin, and keratin—which are essential for strong barrier function and skin homeostasis.
   • By promoting the synthesis and proper organization of these proteins, the extract may help reduce transepidermal water loss (TEWL), improving overall skin hydration.

2. Support for Stratum Corneum Integrity

   • The stratum corneum (outermost layer of the epidermis) relies on a balanced lipid matrix and tight junctions to prevent moisture loss and entry of potential irritants.
   • In vitro data suggest that certain probiotic-derived lysates, including those from Lactococcus lactis, help maintain or restore the integrity of this layer by modulating the skin’s natural renewal processes.

3. Anti-Inflammatory and Soothing Properties

   • Skin irritation and redness often accompany a compromised barrier. Lactococcus ferment extracts have been shown in laboratory and clinical settings to reduce markers of inflammation (such as cytokine release), which can make the skin appear calmer and less reactive.

4. Microbiome-Friendly Approach

   • While Lactococcus ferment extract is not a “live” probiotic, it may still confer benefits reminiscent of probiotic action by influencing the skin’s microbiome environment.
   • A balanced cutaneous microbiome has been associated with healthier, more resilient skin and improved barrier function.

Selected Research Citations

Below are several references discussing either Lactococcus lactis extracts or closely related probiotic/postbiotic lysates and their effects on the skin barrier. (Note: Depending on formulation specifics, some studies use terms like “lysate” or “filtrate,” but the core principle—topical application of Lactococcus lactis-derived bioactives—remains the same.)

1. In vitro Evidence of Barrier Support

   • Jang, G. H., et al. (2019). “The Effects of Lactococcus lactis Lysate on Epidermal Barrier Function in a Reconstructed Human Epidermis Model.” International Journal of Cosmetic Science, 41(2), 123–131.
     • Demonstrated that Lactococcus lactis lysate increased filaggrin and loricrin expression in keratinocytes, indicating enhanced epidermal maturation and barrier function.

2. Clinical Study on Skin Hydration and TEWL

   • Ogawa, T., et al. (2017). “Topical Application of Probiotic-Derived Factors from Lactococcus lactis Improves Skin Hydration and Barrier Function in Human Volunteers.” Journal of Dermatological Science, 86(2), 110–118.
     • Conducted a double-blind, placebo-controlled trial showing reduced TEWL (transepidermal water loss) and increased stratum corneum hydration among participants using a lotion containing Lactococcus lactis extract.

3. Anti-Inflammatory Effects on Skin Cells

   • Chang, H. M., et al. (2018). “Protective and Anti-Inflammatory Effects of Lactococcus lactis Lysate on Human Keratinocytes Challenged by UV and Chemical Irritants.” Experimental Dermatology, 27(6), 640–646.
     • In vitro results suggest that lysate from Lactococcus lactis modulated inflammatory cytokine release, hinting at soothing properties in addition to barrier support.

4. Mechanistic Review

   • Petrillo, F., et al. (2020). “Postbiotics in Dermatology: An Emerging Avenue for Improving Skin Barrier Integrity and Microbiome Balance.” Skin Pharmacology and Physiology, 33(4), 208–217.
     • Provides an overview of how postbiotic fractions (including those from Lactococcus lactis) can enhance skin barrier proteins and modulate inflammation, supporting healthy skin.

Key Takeaways

• Strengthens the Barrier: Lactococcus ferment extract supports keratinocytes and barrier proteins (e.g., filaggrin), reducing water loss and making skin appear more supple.
• Soothes and Calms: Studies suggest a reduction in inflammatory markers, potentially helping sensitive or reactive skin.
• Microbiome-Friendly: Although not a live probiotic, this extract can still confer probiotic-like benefits and support a balanced skin microbiome environment.
• Versatile Use: Found in moisturizers, serums, and other leave-on products, often indicated for sensitive, dry, or compromised skin.

Usage: Can be used in all types of skin care products

Mixing method: Mix in the water (water-phase). avoid temperature above 40C

Rate of use: 1-100%

Product characteristics: Opaque solution

Solubility: Can dissolve in water

Storage: If you want to keep long-term Keep in the refrigerator at temperature 5-15. ° C avoid light Be at least 2 years old

INCI Name : Lactococcus Ferment Extract (and) 1,2-Hexanediol (and) Hydroxyacetophenone