a highly concentrated of RG2 group of Ginsenoside that found to have anti-aging skin benefits

RareGinseng®-Rg2 is a highly concentrated of Rg2 group of Ginsenoside

Contains a minimum of 13,000ppm of Rg2 Ginsenoside, and total Ginsenosides of 20,000ppm minimum

(Please read more research detail from the attached file)

The scientific findings from the document regarding the topical benefits of ginsenoside Rg2 are as follows:

1. Inhibition of MMP-1 Expression: Rg2 was shown to downregulate the expression of matrix metalloproteinase-1 (MMP-1) in human fibroblasts (Hs68 cells) that were treated with UVB-irradiated keratinocyte-conditioned medium (UV CM). MMP-1 is a collagenase that plays a key role in collagen degradation, which is associated with skin aging and wrinkle formation.

2. Concentration-Dependent Effects: The inhibitory effect of Rg2 on MMP-1 gene and protein expression was found to be concentration-dependent. Specifically:

   • At 12.5 µM, 25 µM, and 50 µM concentrations, Rg2 significantly inhibited MMP-1 expression without causing cytotoxicity in Hs68 cells.
   • The maximum effect was observed at a concentration of 50 µM.

3. Mechanism of Action: The study showed that Rg2 inhibits the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), which are part of the mitogen-activated protein kinase (MAPK) signaling pathway. However, Rg2 did not affect the phosphorylation of p38 MAPK. This suggests that Rg2 interferes with specific pathways that lead to MMP-1 expression.

4. Cytotoxicity Assessment: Rg2 at concentrations up to 50 µM did not exhibit cytotoxic effects on Hs68 cells. However, a concentration of 100 µM combined with UV CM showed cytotoxicity, reducing cell viability to 78.9 ± 2.55%.

5. Implications for Photoaging Prevention: The ability of Rg2 to inhibit MMP-1 suggests it has potential applications in preventing photoaging, which is the aging of the skin caused by exposure to ultraviolet (UV) radiation. By reducing MMP-1 levels, Rg2 helps maintain collagen integrity and skin elasticity, thereby potentially reducing wrinkle formation and other signs of aging.

Use: for wrinkle reduction products Available in the form of gel, serum, lotion or cream.

How to mix:  The temperature of cosmetics must be below 40 °C

Utilization rate: 0.1-5% (recommend 3%)

Product characteristics: Yellow to light brown liquid

Solubility: can dissolve in water

Storage: For long-term storage keep in refrigerator temperature 4 °C -8 °C At least 24 months from the date of manufacture.

INCI Name : Butylene Glycol, Panax Ginseng Extract, Hydrolyzed Ginseng Saponins