It was developed with the aim of reducing the hypersensitivity of the skin (decreased skin sensitivity) causing chronic inflammation and neuralgia. through the process of excitation of neurons in μ-opioid receptors 

Pep®-Sensyl is Acetyl Tetrapeptide-15In the form of a water-soluble powder with a Peptide concentration of 1500ppm.

Acetyl Tetrapeptide-15Concentrations in the range of 1350-1500ppm are often referred to as Skinasensyl.

Acetyl tetrapeptide-15 is a peptide sequence derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), which is a human μ-opioid agonist. Good skin irritation, commonly used in products to reduce irritation, reduce allergies, reduce skin sensitivity

Acetyl tetrapeptide-15It was developed with the aim of reducing the hypersensitivity of the skin (decreased skin sensitivity) causing chronic inflammation and neuralgia. through the process of excitation of neurons in μ-opioid receptors

The efficacy of this peptide was demonstrated both in vitro and on real skin. It was tested for its ability to modulate CGRP release. CGRP is released after TRVP1 activation by Capsaisin.

The test was performed by incubating sensory neurons with acetyl tetrapeptide-15 (0.0003% and 0.001%), capsazepine (10 μM, a TRPV1 antagonist), or verapamil (100 μM, calcium channel blocker) for 6 h, and then incubating. Exposure to KCl and capsaicin, Acetyl tetrapeptide-15 0.001% was found to significantly reduce CGRP release. Both when the neurons were exposed to capsaicin and KCl, which was 10 µm more effective than capsazepine.

A blinded clinical study found the ability of acetyl tetrapeptide-15 to In reducing skin sensitivity after capsaicin exposure in 20 people, the protocol began with increasing concentrations of nasal capsaicin solutions to determine the concentration that caused skin sensitivity. discomfort. Then, a 0.0015% solution containing acetyl tetrapeptide-15 is applied twice a day for four days and were repeated to increase the capsaicin concentration. Overall, the capsaicin threshold was significantly increased. which shows the efficiency of

From various studies, it can be confirmed that Acetyl tetrapeptide-15It can help reduce the sensitivity of the skin, so it is suitable for use in formulas that want to reduce skin irritation.

Use: for products to reduce skin irritation

How to mix: final mix avoid heat water soluble

Utilization rate: 0.3-1%

Product characteristics: white powder

Solubility: can dissolve in water

Storage: For long-term storage keep in refrigerator Do not expose to sunlight, heat, tightly seal the lid.

INCI Name : Mannitol (and) Sodium Citrate (and) Acetyl Tetrapeptide-15