Amino Acids that have been researched to be beneficial for various skin types. Prevents Glycation , Moisturizes skin , Anti-oxidant , Restores skin barrier

L-Carnosine is an Amino Acids that has been researched to confirm that it has many benefits for the skin as follows.

1. Prevent the occurrence of Glycation - Glycation inhibitor and repair [1] [9]

2. Protect skin from UV light damage - Sun damage protection [3] [4]

3. Helps to heal wounds - Wound healing support [11] [12]

4. Moisturizing skin - Moisturizing & hydration [13] [14]

5. Anti-oxidant - Antioxidant [4] [5] [6]

6. Restore skin barrier - Restore skin barrier function [8]

[1] AA Boldyrev, SC Gallant, and GT Sukhich, “Carnosine, the protective, anti-aging peptide,” Biosci. Rep., vol. 19, no. 6, pp. 581–587, Dec. 1999.
[2] C. Renner, N. Zemitzsch, B. Fuchs, KD Geiger, M. Hermes, J. Hengstler, R. Gebhardt, J. Meixensberger, and F. Gaunitz, “Carnosine retards tumor growth in vivo in an NIH3T3- HER2/neu mouse model,” Mol. Cancer, vol. 9, p. 2, 2010.
[3] E. Emanuele, JM Spencer, and M. Braun, “An experimental double-blind irradiation study of a novel topical product (TPF 50) compared to other topical products with DNA repair enzymes, antioxidants, and growth factors with sunscreens: implications for preventing skin aging and cancer,” J. Drugs Dermatol. JDD, vol. 13, no. 3, pp. 309–314, Mar. 2014.
[4] E. Emanuele, M. Bertona, F. Sanchis-Gomar, H. Pareja-Galeano, and A. Lucia, “Protective effect of trehalose-loaded liposomes against UVB-induced photodamage in human keratinocytes,” Biomed. Rep., vol. 2, no. 5, pp. 755–759, Sep. 2014.
[5] MY Kim, EJ Kim, Y.-N. Kim, C. Choi, and B.-H. Lee, “Effects of α-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats,” Nutr. Res. Pract., vol. 5, no. 5, pp. 421–428, Oct. 2011.[6] MA Babizhayev, “Biological activities of the natural imidazole-containing peptidometics n-acetylcarnosine, carcinine and L-carnosine in ophthalmic and skin care products,” Life Sci., vol. 78, no. 20, pp. 2343–2357, Apr. 2006.
[7] MA Babizhayev, AI Deyev, EL Savel'yeva, VZ Lankin, and YE Yegorov, “Skin beautification with oral non-hydrolized versions of carnosine and carcinine: Effective therapeutic management and cosmetic skincare solutions against oxidative glycation and free-radical production. as a causal mechanism of diabetic complications and skin aging,” J. Dermatol. Treat., vol. 23, no. 5, pp. 345–384, Oct. 2012.
[8] G. de C. Dieamant, MDC Velazquez Pereda, S. Eberlin, C. Nogueira, RM Werka, and ML de S. Queiroz, “Neuroimmunomodulatory compound for sensitive skin care: in vitro and clinical assessment,” J. Cosmet. . Dermatol., vol. 7, no. 2, pp. 112–119, Jun. 2008.
[9] VP Reddy, MR Garrett, G. Perry, and MA Smith, “Carnosine: a versatile antioxidant and antiglycating agent,” Sci. Aging Knowl. Environ. SAGE KE, vol. 2005, no. 18, p. pe12, May 2005
[10] C. Rona, F. Vailati, and E. Berardesca, “The cosmetic treatment of wrinkles,” J. Cosmet. Dermatol., vol. 3, no. 1, pp. 26–34, Jan. 2004.
[11] Q. Wessels, E. Pretorius, CM Smith, and H. Nel, “The potential of a niacinamide dominated cosmeceutical formulation on fibroblast activity and wound healing in vitro,” Int. Wound J., vol. 11, no. 2, pp. 152–158, Apr. 2014.
[12] I. Ansurudeen, VG Sunkari, J. Grünler, V. Peters, CP Schmitt, S.-B. Catrina, K. Brismar, and EA Forsberg, “Carnosine enhances diabetic wound healing in the db/db mouse model of type 2 diabetes,” Amino Acids, vol. 43, no. 1, pp. 127–134, Jul. 2012.
[13] A. Federici, G. Federici, and M. Milani, “An urea, arginine and carnosine based cream (Ureadin Rx Db ISDIN) shows greater efficacy in the treatment of severe xerosis of the feet in Type 2 diabetic patients in comparison. with glycerol-based emollient cream. A randomized, assessor-blinded, controlled trial,” BMC Dermatol., vol. 12, p. 16, 2012.
[14] G. Ciammaichella, G. Belcaro, M. Dugall, M. Hosoi, R. Luzzi, E. Ippolito, and MR Cesarone, “Product evaluation of Ureadin Rx Db (ISDIN) for prevention and treatment of mild-to- moderate xerosis of the foot in diabetic patients. Prevention of skin lesions due to microangiopathy,” Panminerva Med., vol. 54, no. 1 Suppl 4, pp. 35–42, Dec. 2012.

Use: for wrinkle products

Mixing method: mix in water Avoid heat above 40 degrees. The formula should have a pH in the range of 3.5-7.0.

*Formula should be used Butylene Glycol or Ethoxydiglycol or Laurocapram at a rate of 3% to help bring L-Carnosine to be absorbed into the skin better*

Usage rate: 0.1-1.0%

Product characteristics: White powder, can't withstand heat over 40 degrees.

Solubility: soluble in water

Storage: Store in a cool place (6-8 degrees). Close the bottle tightly. sealed from the sun The product has a minimum shelf life of 24 months from the date of manufacture.

INCI Name : L-Carnosine

Examples of products that use L-Carnosine

LA ROCHE-POSAY Tolerance Ultra Overnight

Paula's Choice Resist Anti-Aging 10% Niacinamide Booster

STRIVECTIN Active Infusion Youth Serum

Elizabeth Arden Prevage Foundation

Nu Skin ageLOC me serum T1