Anti-inflammatory and Antioxidant, extracted from Propolis

Caffeic Acid Phenethyl Ester (CAPE), particularly when extracted from propolis at a purity of 95%, has been associated with several health benefits as a dietary supplement:

1. Antioxidant Properties: CAPE is known for its strong antioxidant properties, which help prevent oxidative stress by neutralizing free radicals that can damage cells and lead to inflammation and various chronic diseases[3][4].

2. Anti-inflammatory Effects: It has demonstrated potential health benefits in reducing inflammation, which is a common underlying factor in many chronic conditions[2][3][5].

3. Anticancer Activity: CAPE has shown anti-cancer properties in various studies, suggesting it may help prevent cancer or support cancer treatment[2][3][5].

4. Antibacterial and Antifungal Properties: The compound also exhibits antibacterial and antifungal activities, which can contribute to overall health by combating harmful microorganisms[2].

5. Metabolic Disorder Prevention: There is potential for CAPE to prevent obesity and associated metabolic disorders, indicating its role in supporting metabolic health[5].

6. Neuroprotective Effects: CAPE may have neuroprotective properties, which could be beneficial in preventing neurodegenerative diseases like Parkinson's disease[3].

7. Cardioprotective Effects: Its antioxidant and anti-inflammatory effects may also contribute to heart health, potentially reducing the risk of heart disease[3].

8. Support for Athletic Performance: Some studies suggest that CAPE may boost athletic performance and reduce exercise-related fatigue, although more research is needed to confirm these effects[3].

9. Enhancing Cancer Treatment: CAPE has shown promise in reducing toxicity associated with chemotherapy and radiation, potentially leading to better outcomes in cancer treatment[3].

10. Antiviral Abilities: It has been shown to inhibit HIV and may improve overall treatment for the infection when included in the diet[3].

It is important to note that while these benefits are promising, most studies have been conducted in vitro or in animal models. More research is needed to fully understand how CAPE is absorbed in the human body and to determine the proper dosage needed to produce the most benefits in humans. Additionally, the safety and side effects of CAPE supplements have not been extensively studied in humans, and natural products and supplements are not subjected to the same rigorous safety and efficacy requirements as pharmaceutical drugs by regulatory agencies like the U.S. Food and Drug Administration[3].

Citations:
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880688/
[2] https://onlinelibrary.wiley.com/doi/10.1002/ptr.7707
[3] https://www.healthline.com/health/caffeic-acid
[4] https://www.sciencedirect.com/science/article/pii/S1756464623002372
[5] https://www.spandidos-publications.com/10.3892/etm.2015.2346