Cosmetics Formulation Development

Searching for raw materials to replace triclosan (Triclosan) in toothpaste found that there are 2 interesting substances Cetylpyridinium chloride and Four-EO™ I would like to ask if 1 should choose one or not? If yes, which one should I choose to replace and how much ratio should I use (how many %) in toothpaste 2 if I can put both of them? or not, in this case and should be used in pour ratio How much (how many %) of each item in toothpaste? Thanks in advance for advice.

Hello Cetylpyridinium chloride is a safer replacement for Triclosan. and long-term use does not cause tooth blackening like triclosan Four-EO n't be necessary if there is Cetylpyridinium chloride is already in the formula.